Scientists say they may have discovered why more women than men have Alzheimer’s disease and dementia.
It has always been thought that women living longer than men was the reason.
But new research presented at an international conference suggests this may not be the whole story.
Most people living with Alzheimer’s – the most common cause of dementia – are women.
In the UK, about 500,000 women have dementia, compared with 350,000 men.
Most people who develop the disease are over the age of 65 but it is not a normal part of ageing.
Alzheimer’s disease can affect younger people too.
Higher brain connectivity
Researchers from Vanderbilt University Medical Centre studied brain scans of hundreds of men and women, looking at the pattern of a protein called tau.
The researchers found differences between the sexes in how tau was spread across regions of the brain.
With this higher connectivity, women’s brains may be at risk of faster spread of tau – and of cognitive decline.
But she said more research was needed to see if there were ways of using this information to treat people with the disease and reduce the risk of it developing.
Sex-specific genes
Another study, from the University of Miami, found evidence that genes specific to women and men could be linked to Alzheimer’s risk.
The discovery could lead to unique risk profiles for men and women.
However, whether this information can be used to identify men and women at risk of the disease is not yet known.
The research was presented at the Alzheimer’s Association International Conference in Los Angeles.
